Seven-time European champions AC Milan will face Arsenal in the standout last-16 tie in the Europa League after the draw was made in Nyon, Switzerland on Friday.
It will be the first time the two clubs have met since Milan won 4-3 on aggregate to reach the Champions League quarterfinals in 2012 where they lost to Barcelona.
Spanish favourites Atletico Madrid take on Lokomotiv Moscow while Milan's Serie A rivals Lazio will face Dinamo Kiev.